ENGLISH      日本語      中文      РУССКИЙ      العربية      УКРАIНСЬКА      

contact us

Calculation of Risk of Down Syndrome (CaRDS-XEMA)

CaRDS-XEMA projects statistical risk of Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), intrauterine fetal growth retardation and neural tube defect (spina bifida) during 1st and 2nd trimester of pregnancy.

CaRDS-XEMA calculates the correct risk of these disorders by using laboratory, USI and individual patient data. First, CaRDS-XEMA calculates out a current gestational age based on the date and results of USI (input manually) and the date of the last menstrual period (LMP, calculated automatically). Based on the gestational age, CaRDS-XEMA automatically requests to input results for either the 1st or 2nd trimester set of parameters.

Number of the input parameters, their median and SD values for each week of gestation are determined by the user. Median and SD values for the same parameter usually differ between manufacturers. If you work with Xema ELISA kits - PAPP-A, free beta-HCG, AFP, HCG, and unconjugated Estriol – we shall provide you FOC median and SD values obtained by Xema during extensive investigations. If you use tests from another manufacturer – you should either take these data from the relevant IFUs or, if absent, to request them from the manufacturer.

Median and SD values may deviate also in different populations, and CaRDS-XEMA allows you to adjust these values to your specific population to make your risk calculations more precise and reliable. All your statistical data are automatically accumulated in a separate file, and these data may be used for calculation of the user’s own medians characteristic to the population investigated.

To calculate risk, CaRDS-XEMA also uses other associated data including patient’s weight, number of fetuses, patient’s race, and presence of diabetes. CaRDS-XEMA allows results of the 1st trimester to be further defined during the 2nd trimester, and to calculate a cumulative risk index based on results for both trimesters.

For displaying results, CaRDS-XEMA provides several options:

  • - Data displayed on your PC;
  • - A cumulative file which can be easily processed by any laboratory data management system;
  • - A flexible user-defined printout template;
  • - A graphic representation of results